Last week at the 8th Annual Obesity Symposium hosted by the European Surgery Institute in Norderstedt, one of the case presentations included an individual with type 1 diabetes (no insulin production), who had gained weight and subsequently also developed increasing insulin resistance, the hallmark of type 2 diabetes.
In my discussion, I referred to this as 1+2 diabetes, or in other words, type 3 diabetes.
Unfortunately, it turns out that the term type 3 diabetes has already been proposed as the type of neuronal insulin resistance found in patients with Alzheimer’s disease.
As discussed in a paper by Suzanne de la Monte and Jack Wands published in the Journal of Diabetes Science and Technology,
“Referring to Alzheimer’s disease as Type 3 diabetes (T3DM) is justified, because the fundamental molecular and biochemical abnormalities overlap with T1DM and T2DM rather than mimic the effects of either one.”
These findings have considerable implications for our understanding of Alzheimer’s disease as a largely neuroendocrine disorder, which may in part be amenable to treatment with drugs normally used to treat type 1 and/or type 2 diabetes.
In retrospect, I believe, whoever came up with the term type 3 diabetes for Alzheimer’s disease, should perhaps have called it type 4 diabetes, given that the 1+2 diabetes is now increasingly common (and well studied) in patients with type 1 diabetes, who go on to develop type 2 diabetes (which, as discussed at the symposium responds quite well to bariatric or “metabolic” surgery).
Today I will be attending a Summit on Weight Bias at the University of Calgary, that will explore the the issue of weight-based discrimination and ways to address this – especially in health care settings.
It should come as no surprise that weight bias and discrimination are a major barrier to providing proper preventive and therapeutic health care due to the widespread attitudes and beliefs about obesity that exist amongst health professionals and decision makers.
The scientific summit, co-sponsored by the Canadian Obesity Network, Campus Alberta, and the Canadian Institutes of Health Research (CIHR), is complemented by a public Cafe Scientifique that will be held on Thursday, March 12, 7.00 at the Parkdale Community Association, 3512 – 5 Ave NW, in Calgary.
For more information and pre-registration for this free public event, which features
Leora Pinhas, MD
Child & Adolescent Psychiatrist, Physician Lead, Eating Disorders Unit, Ontario Shores Centre for Mental Health Sciences Assistant Professor, University of Toronto
Tavis Campbell, PhD
Professor, Department of Psychology and Oncology & Director, Behavioural Medicine Laboratory, University of Calgary
Yoni Freedhoff, MD, CCFP
Medical Director, Bariatric Medical Institute, Assistant Professor, University of Ottawa
It would hardly come as a surprise to regular readers that I would be delighted to see the Edmonton Obesity Staging System featured quite prominently in the article on obesity management by Dietz and colleagues in the 2015 Lancet series on obesity.
Here is what the article has to say about EOSS:
“The Edmonton obesity staging system (EOSS) has been used to provide additional guidance for therapeutic interventions in individual patients (table 1). EOSS provides a practical method to address the treatment paradigm. In principle, EOSS stages 0 and 1 should be managed in a community and primary care setting. Recent data from the USA suggest that 8% of patients with severe obesity (BMI ≥35 kg/m²) account for 40% of the total costs of obesity, whereas the more prevalent grade 1 obesity accounts for a third of costs. These findings suggest that greater priority should be accorded to EOSS stages 3 and 4, resulting in greater focus on pharmacological and surgical management delivered in specialist centres.”
These recommendations are not surprising, as EOSS was specifically designed to provide a much better representation of how “sick” a patient is rather than just how “big” she is.
This is why EOSS has now found its way not just into the 5As of Obesity Management framework of the Canadian Obesity Network but also into the treatment algorithm of the American Society of Bariatric Physicians.
To download a slide presentation on how EOSS works click here.
Following the recent guest posts by Drs Vera Tarman and Pam Peeke on food addiction, many readers have left comments about how this notion rings true to them and how the ideas of treating their “eating disorder” as an addiction has helped them better control their diet and often lose substantial amount of weight.
Others have asked how to tell if they might be food addicts. For them, I am reproducing the following list of 20 questions taken from Food Addicts in Recovery Anonymous.
Although it is important to note that “food addiction” has yet to be officially recognized as a medical/psychiatric condition and the following questions are by no means “diagnostic”, I would still support the idea that the more of these questions you answer with yes, the more likely you may benefit from discussing this problem with someone who has expertise in addictions (rather than simply going of on another diet or exercise program).
1. Have you ever wanted to stop eating and found you just couldn’t?
2. Do you think about food or your weight constantly?
3. Do you find yourself attempting one diet or food plan after another, with no lasting success?
4. Do you binge and then “get rid of the binge” through vomiting, exercise, laxatives, or other forms of purging?
5. Do you eat differently in private than you do in front of other people?
6. Has a doctor or family member ever approached you with concern about your eating habits or weight?
7. Do you eat large quantities of food at one time (binge)?
8. Is your weight problem due to your “nibbling” all day long?
9. Do you eat to escape from your feelings?
10. Do you eat when you’re not hungry?
11. Have you ever discarded food, only to retrieve and eat it later?
12. Do you eat in secret?
13. Do you fast or severely restrict your food intake?
14. Have you ever stolen other people’s food?
15. Have you ever hidden food to make sure you have “enough?”
16. Do you feel driven to exercise excessively to control your weight?
17. Do you obsessively calculate the calories you’ve burned against the calories you’ve eaten?
18. Do you frequently feel guilty or ashamed about what you’ve eaten?
19. Are you waiting for your life to begin “when you lose the weight?”
20. Do you feel hopeless about your relationship with food?
Continuing with the theme of food addiction, here is another guest post – this one by Dr. Pam Peeke, a Pew Foundation Scholar in Nutrition, Assistant Clinical Professor of Medicine at the University of Maryland, and Senior Science Advisor to Elements Behavioral Health, the USA’s largest network of residential addiction treatment centers. She is author of the New York Times bestseller The Hunger Fix: The Three Stage Detox and Recovery Plan for Overeating and Food Addiction. Her website is http://www.drpeeke.com/
For years, the popular culture has embraced the relationship between food and addiction. It permeates our daily vernacular— “I’m hooked on bread”, “I need a candy fix”, “I can’t get off the stuff”, “I’m a carb addict”. Grocery store shelves are filled with colorful cereal boxes labeled “Krave”, as the food industry capitalizes on the consumers’ never ending hunger for another fix. History was made when a major weight management company aired its first Super Bowl commercial, choosing a “food as drug” theme, narrated by Breaking Bad actor Aaron Paul. Close your eyes, listen to the words, and you’d never guess that food, not drugs, was the focus. Companies and communities, however, cannot validate the phenomenon of addictive eating behavior—only science can do that.
Heeding the call to arms, nutrition and addiction researchers, led by Dr. Nora Volkow, Director of the National Institute of Drug Abuse, have spent the past ten years generating a critical mass of valid and credible science associating specific food products and addictive eating behavior. A tipping point was reached in 2012, when the peer reviewed and edited professional textbook Food and Addiction was published. A month later my consumer book, The Hunger Fix: The Three Stage Detox and Recovery Plan for Overeating and Food Addiction, was released and the single most common response from my readers was “What took you so long?” We needed, and finally benefited from, new groundbreaking research.
We now know that certain foods, namely the “hyperpalatables”–sugary, fatty, salty food combinations— affect the brain’s reward center in a way identical to drugs and alcohol, triggering an abnormally high level of release of the pleasure chemical dopamine. Repeated hyper-stimulation of these reward pathways can trigger neurobiological adaptations that can lead to compulsive consumption despite negative consequences.
In 2009, Yale researchers developed the first assessment tool, the Yale University Food Addiction Scale, or YFAS, to identify individuals who demonstrated an addictive response to specific foods. Subsequent studies using the scale have shown that there is a wide spectrum of people who present with addictive eating behavior, especially in those who are overweight/obese, female, over 35, or who have existing disordered eating patterns such as binge eating disorder or bulimia. Ongoing investigations have noted that among women, there is a 90 percent association between food addiction and prior history of abuse, especially in childhood and adolescence. As well, the incidence of addictive eating in women increases with post-traumatic stress syndrome.
As scientific evidence continues to mount clarifying the connection between food and addiction, attention is now beginning to focus on treatment options. Treatment for addictive eating behavior is of particular interest to me as a scientist and a clinician. I recall one of my patients, a former alcoholic with a disabling sugar addiction, declaring, “If drinking is black and white – I drink or I don’t– sugar is more shades of grey than there are books.” Indeed, in contrast to drugs and alcohol, treatment for the psychobiological challenges of addictive eating is far more complex. In a prior blog, Dr. Vera Tarman addressed abstinence as one treatment option.
Who is the target treatment population? It’s not just obese, compulsive overeaters. It also includes thin, average and mildly overweight men and women experiencing a full range of eating disorders (ED), mood syndromes and substance abuse. Within these groups there are numerous intricate interconnections, interrelationships and co-occurrences. For instance, current research suggests that approximately 50% of those with an ED are also substance abusers, including 57% of men with binge eating disorder experiencing long-term drug and alcohol abuse. Cross addictions abound as people transition from drugs to cupcakes, from alcohol to sugar, and from bariatric surgery to alcohol. This complicated web of interrelationships is one reason that determining the precise prevalence of food addiction is such a challenge.
In essence, the larger the treatment population, the wider the spectrum of therapeutic modalities required, and thus, the greater the need to individualize and customize treatment for addictive eating behaviors. To address this challenge, I have created the Integrative Nutrition and Holistic Lifestyle Program at Malibu Vista in California. This women’s residential treatment program treats women, many of whom have co-occurring mood and food conditions, specifically addictive eating. This pilot program has garnered national attention including a recent NBC Today Show segment.
The program’s blueprint is based upon my three pronged, customized approach to: 1. mental/spiritual wellness (MIND); 2. whole food nutrition (MOUTH); and, 3. physical activity (MUSCLE). Therapists use a wide range of cognitive psychotherapeutic methods to treat mental health conditions including trauma. Body movement modalities include yoga, tai chi, and meditative walks to foster an improved mind-body association. Nutritionally, the chefs have eliminated any refined or processed foods, including table sugar and artificial sweeteners. Our culinary nutritionist, who is both a certified chef and registered dietitian, assesses each woman. This includes completion of the Yale Food Addiction Scale, a metabolic evaluation, and documentation of any history of substance abuse and disordered eating. An individualized plan is created and refined during the typical 4-5 weeks in-residence. Through hands-on cooking lessons and nutrition education sessions, individuals can reframe and redefine their relationship with food. Group fellowship is critical to ongoing support and success. Continued coaching continues upon discharge. For example, Sandie, featured in the Today Show segment, is now off her anti-anxiety medications, no longer binges, has halved her diabetes medication, and has thus far removed over 50 pounds of excess weight.
In honoring each woman’s unique story and the complexities of treating addictive eating behavior, the Malibu Vista team draws upon elements found from a multitude of resources, including but not limited to 12-step programs. Individualized strategies are designed to use a wide range of interventions to optimize body-brain-mind healing. The end goal is to help each person manage the triple challenge posed by the food-mood-addiction triad, and in doing so, create a blueprint for long term recovery, and success in navigating addictive eating’s many shades of grey.