Yesterday, the Health Quality Council of Alberta, released a report called Overweight and obesity in adult Albertans: a role for primary healthcare, which provides an in-depth analysis of the prevalence, burden, and rates of use of a number of key healthcare services for overweight and obese individuals in Alberta. The report also provides a strong rationale for the role of primary healthcare in weight management for adult Albertans living with overweight and obesity.
In 2014, the HQCA conducted a survey of adult Albertans about their use and satisfaction with healthcare services. As part of this survey, self-reported height and weight were collected from individuals in order to calculate their body mass index. According to these findings, nearly six out of 10 Albertans over the age of 18 were either overweight or obese. The estimated provincial prevalence of adults with overweight and obesity was 35.2 per cent and 23.9 per cent, respectively. In addition, obesity was associated with an increased risk of multiple comorbidities, greater use of healthcare system services, and a lower self-rated individual quality of life.
Managing overweight and obese populations, as well as comorbid conditions, falls predominantly on primary healthcare providers. Evidence shows that diverse strategies for the management of overweight and obesity within primary healthcare are associated with benefits in weight management; however, the most effective mix of providers, interventions, and duration requires further evaluation. Moving forward, Alberta may benefit from working towards a more unified strategy for weight management that includes opportunities to engage Albertans in discussions about weight management, and to increase the use of team-based care across all weight categories.
The full report is available here.
A fact sheet is available here.
To conclude this brief series on our new exhaustive review of the putative health benefits of long-term weight-loss maintenance, published in Annual Reviews of Nutrition, here is the summary paragraph of our findings:
“Obesity is well recognized as a risk factor for a wide range of health issues affecting virtually every organ system. There is now considerable evidence that intentional weight loss is associated with clinically relevant benefits for the majority of these health issues. However, the degree of weight loss that must be achieved and sustained to reap these benefits varies widely between comorbidities. Downsides of weight loss that is too rapid and/or extreme may occur, as in the increased risk of gallbladder disease, the presence of excess residual skin, or deterioration in liver histology. Uncertainty also remains about the potential benefit or harm of intentional weight loss on patients presenting with some chronic diseases and on overall mortality. Clearly, well- controlled prospective studies are needed to better understand the natural history of obesity and the impact of weight-management interventions on morbidity, quality of life, and mortality in people living with obesity.”
The is much left to be done and answering some of these questions will become progressively easier as better treatments for obesity become available.
In our exhaustive review of the potential health benefits of intentional long-term weight loss, published in Annual Reviews in Nutrition, I discussed in yesterday’s post, we also noted a number of issues that remain unresolved.
- The precise definition of success in terms of weight loss remains controversial, and the dogmatic assumption that prolonged periods of sustained weight loss (greater than 10 years) are more likely than shorter periods to have a beneficial effect on health out- comes has never been challenged.
- Some evidence suggests that intentional weight loss may lead to meaningful reductions in several conditions, such as COPD, and cancer risk with a short latency time, although data from randomized trials are not yet available to support this hypothesis.
- Future studies on the relationship between long-term weight loss and suicide are needed, especially in diverse populations, subgroups of patients, and those who engage in other long-term weight-loss strategies apart from the use of antiobesity medications and bariatric surgery. The potential relationship between failed weight-loss attempts and suicide ideation needs to be evaluated.
- There is ongoing controversy over the findings from epidemiological studies on the relationship between weight loss and mortality. Data from controlled studies in this regard are very limited.
Clearly, as we discussed at length here at the ongoing Canadian Obesity Network’s Obesity Research Summer School (Boot camp), much remains to be done for young researchers planning a career in this field.
While the health benefits associated with intentional weight loss for some complications of obesity (such as elevated lipids and diabetes) are well documented, high-quality studies to back many other potential health benefits are harder to find.
Just how well (or poorly) the putative health benefits of long-term intentional weight loss are documented for each of the many conditions associated with obesity, is now detailed in a comprehensive review of the literature that we just published in the Annual Reviews of Nutrition.
The 40 page long review, which includes almost 250 relevant publications, supports the following main findings:
- Defining and assessing clinically relevant obesity and weight change are challenging tasks. In a given individual, there is often little relationship between the magnitude of obesity and measures of health.
- Despite its modest effect on long-term weight loss, behavioral modifications thatimprove eating behaviors and increase physical activity constitute a cornerstone for integral and sustainable weight management.
- Intentional weight loss is associated with a clinically relevant reduction in blood pressure, improvement in cardiac function, and reduction in cardiovascular events. The duration and magnitude of weight change required to achieve a significant benefit are still unclear.
- In individuals with impaired glucose metabolism at any stage, intentional weight loss achieved by any means is associated with a proportional reduction in T2DM prevalence, severity, and progression.
- Intentional weight loss is consistently associated with a clinically relevant reduction in triglycerides and increase in HDL cholesterol. The effects of weight loss on LDL cholesterol are less consistent.
- Overall, nonalcoholic fatty liver disease is commonly associated with excess weight and can show marked improvement with behavioral, pharmacological, and/or surgical weight loss. Very rapid weight loss, however, may worsen liver histology in some patients. Simi- larly, gallbladder disease is not only common in patients presenting with obesity but also highly prevalent after intentional weight loss.
- Obesity is widely recognized as a key modifiable risk factor for osteoarthritis, with sig- nificant improvements in pain and function reported with weight loss.
- Obstructive sleep apnea and obesity hypoventilation syndrome tend to improve with moderate weight loss; however, complete resolution is not common and is related to very significant weight loss.
- Asthma and COPD are clearly associated with obesity. Sustained weight loss seems to be associated with a significant improvement in asthma symptoms. Data for COPD are rather limited.
- Pregnant women who under go bariatric surgery seem to be less likely to present obstetric complications such as gestational diabetes, preeclampsia, and macrosomia.
- Data on weight loss and suicide are controversial. Caution may be in order when con- sidering bariatric surgery in patients with a history of suicide ideation or attempt.
- Data suggest that long-term weight loss is associated with an improvement in health- related quality of life. The amount of weight loss required to achieve a significant change, however, remains controversial.
However, there are many other issues where putative benefits of intentional weight loss remain even less clear than with the above.
For many conditions we will likely not know the long-term benefits of obesity treatments till better treatments become available and are tested in affected individuals.
But just how much evidence is there that any of this is actually beneficial to your health (i.e. if you are not a mouse).
This question was addressed by Benjamin Horne and colleagues from Salt Lake City, Utah, in a paper published in the American Journal of Clinical Nutrition.
The researchers review the evidence on various forms of fasting from the published literature, which consists of a grand total of three randomised controlled trials, together involving about 100 participants, with durations ranging between 2 days to 12 weeks.
Although all three trials reported some benefits in terms of body weight, cholesterol and other surrogate markers, the authors failed to find any study that looked at actual clinical endpoints (e.g., diabetes or coronary artery disease].
To be fair the authors did find two observational studies in humans (both involving the first author of this study), where fasting was associated with a lower prevalence of heart disease or diabetes but, as readers should be well aware, these types of studies cannot prove causality.
I guess it would be fair to say that the popular enthusiasm about the health benefits of various forms of fasting, as far as their benefits for humans are considered, appear largely based on hope and hype – at least as far as clinically meaningful outcomes are concerned.
This is not to say that fasting, whether alternative day or otherwise, may not well have some medical benefits – fact is, we just don’t know.
Or rather, as the authors put it,
“whether fasting actually causes improvements in metabolic health, cognitive performance, and cardiovascular outcomes over the long term; how much fasting is actually beneficial; and where the threshold of hormesis resides (i.e., a balance between long-term benefit from fasting compared with harm from insufficient caloric intake) remain open questions….considerable additional clinical research of fasting is required before contemplating changes to dietary guidelines or practice.”