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Effect Of Sleep Deprivation And Meal Timing On Insulin Sensitivity



sharma-obesity-sleep-deprivationAs we continue learning more about the complexity of appetite and energy balance, sleep and circadian rhythm are emerging as important variables.

Now a study by Robert Eckel and colleagues, published in Current Biology, illustrates how sleep deprivation and timing of meals can markedly alter insulin sensitivity.

Studies were conducted in 16 healthy young adults (8w) with normal BMI. Following a week of 9-hr-per-night sleep schedules, subjects were studied in a crossover counterbalanced design with 9-hr-per-night adequate sleep (9-hr) and 5-hr-per-night short sleep duration (5-hr) conditions lasting 5 days each, to simulate a 5-day work week. Sleep was restricted by delaying bedtime and advancing wake time by 2 hr each.

Energy balanced diets continued during baseline, whereas food intake was ad libitum during scheduled wakefulness of 5- and 9-hr conditions.

Overall, the simulated 5-day work week  of 5-hr-per-night sleep together with an ad libitum diet resulted in a 20% decrease in oral and intravenous insulin sensitivity, which was compensated for by increased insulin secretion..

These changes persisted for up to 5 days after restoring 9-hr sleep opportunities.

The authors also showed that shifting circadian rhythm resulted in morning wakefulness and eating during the biological night, a factor that may promote weight gain over time.

 

These findings have important implications not just for shift workers but for all of us, who may not be getting adequate amounts of restorative sleep.
Paying more attention to sleep and its impact on appetite and metabolism may need to find its way into routine clinical practice.
@DrSharma
Vienna, Austria

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