Weight Gain in the Elderly is OK?Wednesday, November 19, 2008
As blogged yesterday, excess weight is a well-established risk factor for mortality. But does this relationship hold across the lifespan? – or in other words – does it matter at what age you first gain weight?
This was the question addressed by Ian Janssen and Eric Bacon from Queen’s University, Kingston, Ontario, who examined the effect of current and midlife obesity status on mortality risk in the elderly, in a paper just out in OBESITY.
Analyses were based on 3,238 participants from the original Framingham Heart Study (FHS) cohort who lived to at least 70 years of age and who had BMI measures from when they were in their 50s.
Within this group of 70-year olds, obesity based on current BMI was associated with a 21% increased risk of mortality (P = 0.019) whereas obesity in 70-year olds based on BMI measures obtained at around 50 years of age was associated with a 55% increased risk of mortality (P < 0.0001).
However, and perhaps more importantly, compared to 70-year olds who were nonobese at both 50 and 70 years of age, mortality risk was increased by 47% (P < 0.001) in those who were obese at both 50 and 70 years of age, increased by 56% (P < 0.001) in those who were obese at 50 years of age and nonobese at 70 years of age, but not significantly different (P > 0.9) in those who were nonobese at 50 years of age and obese at 70 years of age.
Thus, although mortality risk was increased in obese older adults who were already obese at midlife, this was not the case for newly obese older adults.
In practical terms this means that if you are lean most of your life but only gain weight when you get to 70 – you are probably OK.
On the other hand, if you were obese at age 50, but somehow lost the weight by the time you got to 70, your risk was still higher than someone who was never obese.
Remember, as with the obesity paradox for individuals with chronic disease, (unintentional) weight loss in the elderly is never a good prognostic sign.
So, if you make it to 70 without gaining too much excess weight – apparently, it’s time to eat, drink and be merry – and don’t sweat the waistline.