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Obesity, Diabetes, and Cancer



Metastasizing Cancer Cell

Metastasizing Cancer Cell

Today, at the EASD in Stockholm, the focus is on obesity.

Later today, I will be presenting an overview of the etiological assessment and management of obesity in a plenary session also featuring Eric Westman (USA), speaking on low-carbohydrate interventions, and Jim Levine (USA), speaking on non-exercise activity thermogenesis (NEAT).

I also have the privilege of chairing a poster session on adipose tissue and inflammation.

But this morning, I attended a session devoted to obesity, diabetes and cancer.

As regular readers will be well aware, obesity accounts for almost 30% of all cancers – and one of the main reasons why bariatric surgery reduces mortality is because of its profound effect on cancer-related mortality.

Regarding the potential molecular link between excess weight and cancers, Jeff Holly (UK), spoke about the important role of metabolic pathways in determining cancer risk.

As Holly pointed out, we all carry countless gene mutations that are potentially cancerogenic in many of our cells (e.g. in the skin, colon, prostate, etc.) and that the number of these cancerous cells increases dramatically with age.

Fortunately, however, we also have very effective systems that keep these cancerous cells in check, which is why most of these cancer cells never develop into clinical disease.

Nevertheless, we know that these defense mechanisms can be substantially influenced by environmental factors. Thus, for e.g. migration and adoption studies show that moving into a western lifestyle, can quickly increase the risk of cancer, not by increasing the number of gene mutations, but rather by affecting the mechanisms that normally keep these early cancerous growths in check.

Even in studies on highly penetrant cancers like breast cancers caused by BRCA mutations, the actual development of clinical cancer varies with environmental exposure.

In his talk, Holly reviewed the role of the insulin-signaling pathway, which also appears to play a key role in tumorgenesis pathways. A key molecule here is Insulin-like Growth Factor (IGF) -1, higher levels of which appear to be associated with higher risk of cancer.

IGF-1 levels can be affected by many environmental factors, which affect genes involved in metabolic pathways relevant to cancer growth.

But substrate availability may also be important. Thus, in vitro studies show that high lipid and glucose levels can both promote the growth of cancerous cells and/or reduce their sensitivity to chemotherapeutic agents.

In summary, metabolic pathways can play a key role in promoting growth of the many pre-cancerous cells – thereby increasing the risk of these cells growing into clinical cancer. This of course provides a sound rationale for the observation that lifestyle factors can have such an important role in reducing the risk of cancers.

Following this presentation, I was particularly delighted to listen to Tobias Pischon from the German Institute of Nutrtition (DIFE), Potsdam-Rehbrucke, further discussing the association between obesity and cancer. Tobias, incidentally, is a former student of mine, whose MD thesis I had the privilege of supervising, before he went off to spend time at the Harvard School of Public Health.

Pischon pointed out that the link between obesity and cancer is not just related to excess weight, but rather to the presence of abdominal obesity, which readers will know, is the kind of fat distribution that is most relevant for the metabolic complications of excess weight.

Thus, as for cardiovascular and metabolic risk, BMI is not the best measure of cancer risk, but rather, increased cancer risk is far ore closely related to waist circumference (a surrogate for abdominal obesity). In fact, as Pischon demonstrated on the large EPIC data set, adding waist circumference to BMI resulted in a much better prediction of cancer risk than using BMI alone.

Thus, I guess if we continue to call obesity a “lifestyle” disease, I guess we can only say the same for most common cancers.

I herewith officially coin the term “lifestyle cancers” – a term that I am sure many people with cancer or cancer-survivors would probably not like to be labelled with (in the same manner that people with obesity don’t like the term “lifestyle” associated with their condition).

AMS
Stockholm, Sweden

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5 Comments

  1. I am wondering if you could clarify two of your statements, and provide a few studies that support them. I find them quite profound and would like to share them with proper references. What are the major publications stating that obesity accounts for 30% of all cancers? Does it actually account or is it associated? Secondly, what papers support that bariartric surgery reduces mortality due to its effect on cancer-related mortality? Many thanks for the interesting read!

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  2. Here’s one reference on cancer reduction with bariatric surgery: Effects of bariatric surgery on cancer incidence in obese patients in Sweden (Swedish Obese Subjects Study): a prospective, controlled intervention trial.
    Sjöström L, Gummesson A, Sjöström CD, Narbro K, Peltonen M, Wedel H, Bengtsson C, Bouchard C, Carlsson B, Dahlgren S, Jacobson P, Karason K, Karlsson J, Larsson B, Lindroos AK, Lönroth H, Näslund I, Olbers T, Stenlöf K, Torgerson J, Carlsson LM; Swedish Obese Subjects Study.
    Lancet Oncol. 2009 Jul;10(7):653-62. Epub 2009 Jun 24.

    The paper also contains ample references on this issue – you’ll find additional information on this topic by searching my website.

    Hope this helps,

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  3. It seems to be that whether to gain weight around your waist or lower down, on your hips, it mostly determined by your genetic makeup. So, I don’t really see how it can be caused by lifestyle. No matter how good my lifestyle is, I can’t control where I gain weight!

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  4. Also, one of the reasons why cancer rates are higher in western countries is that people live much longer in the west than they do in many poor countries. In poor countries, a large part of the population does not live long enough to develop cancer. If we are being killed by our western lifestyle, why is it that we are so relatively long lived?

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  5. At least the IGF-1 data presented on the meeting leave the impression that the insulin glargine – cancer association could be true fact as glargine has higher affinity to the IGF-1 receptor.
    The other question is whether obesity stage 0 (Alberta score) will have higher cancer risk, too?

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