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An Update On Non-Alcoholic Fatty Liver Disease

Of all of the common complications of obesity, fatty liver disease is perhaps the most insidious. Often starting without clinical symptoms and little more than a mild increase in liver enzymes, it can progress to inflammation, fibrosis, cirrhosis and ultimate liver failure. It can also markedly increase the risk for hepatocellular cancer even in patients who do not progress to cirrhosis. Now, a pa… Read More »

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Taking Off Pounds Sensibly Works For Those Who Stick With It

Although the same can probably said for most ethical weight management programs, actual data on the long-term benefits of sticking with a structured weight management program are hard to come by. This is why the recent paper by Nia Mitchell and colleagues from the University of Colorado, published in the American Journal of Preventive Medicine is of considerable interest. The study looks at long-t… Read More »

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Why Presence Of A Comorbidity May Not Be Enough To Decide Who Will Benefit From Bariatric Surgery

Irrespective of the fact that bariatric surgery has now become so safe (at high-volume centres) that it compares well with other common surgical procedures like having your gall bladder removed, it is still surgery. As even the safest surgery carries risk, it should never be taken lightly and thus the question of whether or not people with obesity but no related comorbidities stand to benefit from… Read More »

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Do Genetics Explain Variability in Weight-Loss Response to Liraglutide?

As with any medication (for anything!) not everyone responds the same. Now a small study by Mojca Jensterle and colleagues from Ljubljana, published in the European Journal of Clinical Pharmacology, reports that genetic variability in the GLP-1 receptor gene may predict the variability to the human GLP-1 analogue liraglutide, now approved for obesity treatment in the US, Canada and Europe. In thei… Read More »

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How Your Gut Tastes What You Eat

If you thought that the only senses that determine the palatability of food are your sense of taste and smell, you may be wrong. It turns out that we have a rather sophisticated sensing mechanism in our gut that senses the composition of our diet and interacts with the brain to regulate our appetite and food intake. Just how exactly this gut “nutrient-sensing” system works, is reviewed… Read More »

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