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Targeting Gut Inflammation Can Reduce Insulin Resistance?

With all of the recent interest in the gut microbiota as a mediator of systemic inflammation and metabolic disease, it was only a matter of time before researchers would begin targeting pro-inflammatory pathways in the gut to change metabolism. A proof-of-principle, that this is indeed possible, is presented by Helen Luck and colleagues from the University of Toronto in a paper published in Cell M… Read More »

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Online Course on Weight Bias With Dr. Sara Kirk

Regular readers will be well of the very real social and health impact of weight bias and discrimination. Now, Sara Kirk of Dalhousie University, Halifax, NS, invites you to join her free Massive Open Online Course (MOOC), on weight bias and stigma in obesity, which will be starting on April 20th 2015 (just a week before the Canadian Obesity Summit in Toronto). The course builds on Kirk’s ex… Read More »

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Does Intentional Weight Loss Reduce Mortality?

Given that virtually every risk-factor guideline (from hypertension to diabetes) recommends “weight-loss” as “first-line” treatment, to many this may seem a rather stupid question, but in reality, there is in fact almost no high-qulaity evidence to show that intentional (non-surgical) weight loss actually reduces mortality. This may well be simply because randomised control… Read More »

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Adverse Metabolic Effects of Exercise?

Warning – this is not an April Fool’s post! Rather, it is a follow up to yesterday’s post warning that even “lifestyle” or behavioural interventions can have adverse effects – at least for some people. Point in case, is this paper by Claude Bouchard and colleagues, published in PLOS one back in 2008, clearly documenting clinically significant harmful metabolic e… Read More »

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All Behavioural Interventions Carry Risks

Following the recent release of the Canadian Task Force on Preventive Health Care guidelines for prevention and management of adult obesity in primary care, the Task Force yesterday issued guidelines on the prevention and management of childhood obesity in the Canadian Medical Association Journal (CMAJ). Key recommendations include: For children and youth of all ages the Task Force recommends grow… Read More »

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