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MetAP2 Inhibitor Beloranib Produces Weight Loss in “Simple” Obesity

Readers may recall a previous post on the remarkable efficacy of beloranib, a methionine aminopeptidase 2 (MetAP2 ) inhibitor, in patients with hypothalamic obesity. Now, a paper by Dennis Kim and colleagues present the results of a phase II study in individuals with “simple” obesity, published in Diabetes, Obesity and Metabolism. The study included 147 participants with moderate obesi… Read More »

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Fear of Fat: Promoting Health In a Fat-Phobic Culture

Today I will be attending a Summit on Weight Bias at the University of Calgary, that will explore the the issue of weight-based discrimination and ways to address this – especially in health care settings. It should come as no surprise that weight bias and discrimination are a major barrier to providing proper preventive and therapeutic health care due to the widespread attitudes and beliefs… Read More »

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Treating Obesity Seriously Starts By Understanding The Problem

That there are no easy solutions to obesity and managing your weight is challenging at the best of times. But trying to find manage it without understanding even the basics of how your body works to defend its weight is hopeless at best. A sort paper by Christopher Ochner and colleagues, published in The Lancet Diabetes and Endocrinology, succinctly describes the challenges, and appeals to clinici… Read More »

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Obesity Management Belongs In Primary Care

No matter if and when obesity prevention efforts bear fruit, there are currently well over 6,000,000 Canadian adults and children, who could benefit from obesity management today. Even, if one were to limit more intense obesity management (such as behavioral, pharmacological and/or surgical treatments) to those with more severe obesity (Edmonton Obesity Staging System 2+), this would still overwhe… Read More »

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Patchy Progress on Obesity Prevention – Time To Expand The Food and Activity Paradigm?

In last week’s 2015 Lancet series on obesity, the majority of papers focus on policy interventions to address obesity. It suggests that a reframing of the obesity discussion, that avoids dichotomies (like nature vs. nurture debates) may provide a path forward – both in prevention and management. The policy framework presented by Christina Roberto and colleagues in The Lancet, is based … Read More »

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